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Category Archives: Synthesis Route

The Promise of Peptides: Developments in 3 Key Areas Reawaken Therapeutic Potential

Posted on March 6, 2016 by

In a post last month, we discussed the three types of peptide production techniques Neuland uses to cGMP manufacture peptide APIs and NCEs for clients. We also mentioned some of the…

Posted in APIs, Chemistry, CMC, Contract Manufacturing, drug delivery, drugs, Fmoc, Neuland Labs, peptide, Peptide aggregation, peptides, process chemistry, synthesis, Synthesis Route | Comments Off on The Promise of Peptides: Developments in 3 Key Areas Reawaken Therapeutic Potential

Embracing Green Chemistry

Posted on December 20, 2015 by

There’s an article on Piramal’s Pharma Solutions division at PharmTech about how they are encouraging pharma companies to implement green chemistry earlier in the drug development cycle. Yes, we agree…

Posted in analytical science, API synthesis, APIs, atom economy, Benign-by-Design, Chemistry, CMC, Contract Manufacturing, corporate stewardship, EHS, energy conservation, energy effciency, green chemistry, method development, Neuland Labs, Route Design, Route Scouting, synthesis, Synthesis Route | Comments Off on Embracing Green Chemistry

Green Chemistry and Benign by Design

Posted on September 6, 2015 by

7 ways to boost profits and reduce pharma synthesis waste At Neuland, we’re advocates of green chemistry. Not only is it better for the environment, but it’s also just logistically…

Posted in analytical science, API synthesis, APIs, atom economy, Benign-by-Design, Capabilities, Chemistry, CMC, Contract Manufacturing, EHS, energy conservation, energy effciency, green chemistry, ICH, Impurity profile, Quality, R&D, Route Design, Route Scouting, small molecule, synthesis, Synthesis Route, Uncategorized, zero liquid discharge | Comments Off on Green Chemistry and Benign by Design

6 Properties of API Synthesis that Affect Yield, Delivery Date & Purity

Posted on June 1, 2015 by

I’ve mentioned the importance of route scouting in the past. Now I’d like to share some of the properties of API synthesis that can affect the yield, purity, and delivery date…

Posted in API synthesis, APIs, Chemistry, CMC, Contract Manufacturing, critical reaction parameters, CRO/CMO, method development, Route Design, Route Scouting, synthesis, Synthesis Route | Comments Off on 6 Properties of API Synthesis that Affect Yield, Delivery Date & Purity

Disrupting Peptide Aggregation

Posted on April 22, 2015 by

Earlier this month, I wrote a post about the growth of interest in peptide therapeutics. I wanted to expand on that a bit and share three common Fmoc strategies we…

Posted in Chemistry, Fmoc, peptide, Peptide aggregation, peptides, synthesis, Synthesis Route | Comments Off on Disrupting Peptide Aggregation

The Benefits of Synthesis Scouting

Posted on January 4, 2015 by

The Right Route Can Deliver Fewer Steps, More Consistent Batches, Cleaner Processes…and Cost Savings With drug development and manufacturing processes becoming more complex, alternate synthetic route design is often a…

Posted in Chemistry, CMC, Contract Manufacturing, CRO/CMO, EHS, green chemistry, method development, R&D, Route Design, Synthesis Route | Comments Off on The Benefits of Synthesis Scouting

You Can’t Keep a Good Drug Down

Posted on December 2, 2014 by

Reducing Mutagens, Carcinogens & Other Genotoxins to Improve Safety Profiles There are a number of process modifications API manufacturers can make to improve safety profiles, reduce production costs, improve capacity…

Posted in analytical science, APIs, Capabilities, Chemistry, CMC, Contract Manufacturing, critical reaction parameters, CRO/CMO, drugs, EHS, genotoxic impurities, green chemistry, method development, Neuland Labs, QA/QC, QbD, R&D, regulatory, Route Design, scale-up, Synthesis Route, zero liquid discharge | Comments Off on You Can’t Keep a Good Drug Down