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Category Archives: Peptide aggregation

A Guide to Sourcing Pharmaceutical Peptide APIs

Rise of the Peptide Era                                                                                                                                                       Peptide synthesis has a long pharmaceutical history, stretching back to the early 1900s – and then followed by a lengthy period of dormancy….

Posted in API synthesis, APIs, Capabilities, Chemistry, chromatography, CMC, Contract Manufacturing, CRO/CMO, Fmoc, generic, HPLC, Jitsubo, Molecular Hiving, Neuland Labs, peptide, Peptide aggregation, peptides, process chemistry, Process Engineering, synthesis, Synthesis Route, TIDES | Tagged , | Comments Off on A Guide to Sourcing Pharmaceutical Peptide APIs

How to Select a Peptide Synthesis Technique

Peptides are a complex drug class, and have historically proven challenging from a manufacturing standpoint. They are, however, experiencing a renaissance due to improvements in peptide synthesis, the development of…

Posted in API synthesis, Chemistry, CMC, Contract Manufacturing, method development, peptide, Peptide aggregation, peptides, process chemistry | Comments Off on How to Select a Peptide Synthesis Technique

Purification of Peptides Using Surrogate Stationary Phases on Reversed-Phase Columns

Earlier this month, we published a post on Improving Quality and Yield in Solid Phase Peptide Manufacturing. In recent years, peptides have been acknowledged for their selectivity, efficacy and safety. Combined…

Posted in APIs, Chemistry, chromatography, CMC, HPLC, peptide, Peptide aggregation, peptides, RP-HPLC | Comments Off on Purification of Peptides Using Surrogate Stationary Phases on Reversed-Phase Columns

Tips for Improving Quality and Yield in Solid Phase Peptide Manufacturing

Chemical synthesis of very long peptides and certain sequences considered difficult is always a challenge. In this post, we’ll share a few practical tips for improving various critical aspects of…

Posted in analytical science, API synthesis, APIs, Chemistry, Contract Manufacturing, Fmoc, peptide, Peptide aggregation, peptides, Uncategorized | Comments Off on Tips for Improving Quality and Yield in Solid Phase Peptide Manufacturing

The Promise of Peptides: Developments in 3 Key Areas Reawaken Therapeutic Potential

In a post last month, we discussed the three types of peptide production techniques Neuland uses to cGMP manufacture peptide APIs and NCEs for clients. We also mentioned some of the…

Posted in APIs, Chemistry, CMC, Contract Manufacturing, drug delivery, drugs, Fmoc, Neuland Labs, peptide, Peptide aggregation, peptides, process chemistry, synthesis, Synthesis Route | Comments Off on The Promise of Peptides: Developments in 3 Key Areas Reawaken Therapeutic Potential

Advances in the Synthesis of Peptide Therapeutics: Clear Advantages…and Some Barriers

Although peptides were long passed over for drug development, recent technological advances have prompted the pharmaceutical industry to take a closer look at them. The increased sensitivity, resolution and throughput…

Posted in API synthesis, peptide, Peptide aggregation, peptides, process chemistry | Comments Off on Advances in the Synthesis of Peptide Therapeutics: Clear Advantages…and Some Barriers

Disrupting Peptide Aggregation

Earlier this month, I wrote a post about the growth of interest in peptide therapeutics. I wanted to expand on that a bit and share three common Fmoc strategies we…

Posted in Chemistry, Fmoc, peptide, Peptide aggregation, peptides, synthesis, Synthesis Route | Comments Off on Disrupting Peptide Aggregation