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Category Archives: analytical science

What are Some of the Key Trends in Analytical R&D Labs?

Five years ago this month, we published a post on emerging analytical R&D trends, discussing key techniques such as Multi-Dimensional Liquid Chromatography, Hyphenated Mass Spectrometric Techniques, Error Analysis, Semi-Micro Methacrylate…

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The Need for Speed: Drug Development, Trials & Regulatory Pathways Accelerate in the Wake of COVID-19

For drug makers, speed has always mattered. Every day a drug is delayed on the path to market costs pharma companies millions of dollars. Delays can also lead to the…

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Nitrosamine Impurities and How Companies are Addressing the Crisis

We’ve recently written extensively about nitrosamine impurities, including this in-depth analysis of what transpired with Valsartan, and some follow-up material, here and here. Nitrosamine impurities have been receiving a great…

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Case Studies from Neuland’s Process Engineering Lab

In our PE Lab, a team of 27 highly specialized engineers integrates the key attributes of QbD process understanding, process control, and continuous improvement with advanced equipment, Design of Experiments…

Posted in analytical science, API synthesis, APIs, Capabilities, Chemistry, Design of Experiment, method development, micronization, Neuland Labs, PAT, process chemistry, Process Engineering, QbD, Quality, Route Scouting, Synthesis Route | Comments Off on Case Studies from Neuland’s Process Engineering Lab

Medicine & Science: Keeping Up with the Pace of Change

The changes we’ve witnessed in the fields of science and medicine over the last decade or two have been truly astonishing. When we stood at the beginning of the ‘omics…

Posted in analytical science, API synthesis, Big Data, Capabilities, Chemistry, Neuland Labs, peptide, peptides | Comments Off on Medicine & Science: Keeping Up with the Pace of Change

5 Variables Shaping the Contract Pharma-Client Relationship

Several posts ago, I discussed an article on the ‘shifting sands’ of contract provider/pharma relationships, and how smart providers were responding to pharma’s needs, rather than establishing fixed models of…

Posted in analytical science, API synthesis, Chemistry, CMC, Contract Manufacturing, CRO/CMO, Neuland Labs | Comments Off on 5 Variables Shaping the Contract Pharma-Client Relationship

Tips for Improving Quality and Yield in Solid Phase Peptide Manufacturing

Chemical synthesis of very long peptides and certain sequences considered difficult is always a challenge. In this post, we’ll share a few practical tips for improving various critical aspects of…

Posted in analytical science, API synthesis, APIs, Chemistry, Contract Manufacturing, Fmoc, peptide, Peptide aggregation, peptides, Uncategorized | Comments Off on Tips for Improving Quality and Yield in Solid Phase Peptide Manufacturing

Emerging Trends in Analytical R&D

In the pharmaceutical discovery space, many promising analytical trends have emerged and are now on the rise – and they will see increasing use in drug discovery in coming years….

Posted in analytical science, APIs, Capabilities, Chemistry, chromatography, drug discovery, HPLC, Impurity profile, method development, process chemistry, QA/QC, Quality, R&D, RP-HPLC | Comments Off on Emerging Trends in Analytical R&D

Pharmaceutical API Contract Manufacturing: Reading Room

I’ve been trying to get caught up on some reading this month, and thought I’d put together a roundup of interesting articles I’ve run across recently. Grading GDUFA, at Contract…

Posted in analytical science, API synthesis, APIs, Chemistry, CMC, Contract Manufacturing, CRO/CMO, GDUFA, green chemistry, Pharm Tech, Pharmaceutical Technology, process chemistry | Comments Off on Pharmaceutical API Contract Manufacturing: Reading Room

Embracing Green Chemistry

There’s an article on Piramal’s Pharma Solutions division at PharmTech about how they are encouraging pharma companies to implement green chemistry earlier in the drug development cycle. Yes, we agree…

Posted in analytical science, API synthesis, APIs, atom economy, Benign-by-Design, Chemistry, CMC, Contract Manufacturing, corporate stewardship, EHS, energy conservation, energy effciency, green chemistry, method development, Neuland Labs, Route Design, Route Scouting, synthesis, Synthesis Route | Comments Off on Embracing Green Chemistry