Tafamidis Meglumine

Therapeutic Segment FamilialAmyloidPolyneuropathy/Cardiomyopathy

CAS No. 951395-08-7

Regulatory Filing USDMF, E-DMF

Development Status DMF Filed

Molecule Type Small Molecule

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Mechanism of Action

Tafamidis is a selective stabilizer of TTR. Tafamidis binds to TTR at the thyroxine binding sites, stabilizing the tetramer and slowing dissociation into monomers, the rate-limiting step in the amyloidogenic process.

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