Deferasirox

Therapeutic Segment Iron Chelator

CAS No. 201530-41-8

Regulatory Filing USDMF, CEP

Development Status DMF Filed

Molecule Type Small Molecule

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Mechanism of Action

Deferasirox is an orally active chelator that is selective for iron (as Fe3+). It is a tridentate ligand that binds iron with high affinity in a 2:1 ratio. Although deferasirox has very low affinity for zinc and copper, there are variable decreases in the serum concentration of these trace metals after the administration of deferasirox

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