Dabigatran Etexilate Mesylate

Therapeutic Segment Anticoagulant

CAS No. 872728-81-9

Regulatory Filing USDMF, E-DMF

Development Status DMF Filed

Molecule Type Small Molecule

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Mechanism of Action

Dabigatran and its acyl glucuronides are competitive, direct thrombin inhibitors. Because thrombin (serine protease) enables the conversion of fibrinogen into fibrin during the coagulation cascade, its inhibition prevents the development of a thrombus. Both free and clot-bound thrombin, and thrombin-induced platelet aggregation are inhibited by the active moieties.

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