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Category Archives: R&D

Emerging Trends in Analytical R&D

In the pharmaceutical discovery space, many promising analytical trends have emerged and are now on the rise – and they will see increasing use in drug discovery in coming years….

Posted in analytical science, APIs, Capabilities, Chemistry, chromatography, drug discovery, HPLC, Impurity profile, method development, process chemistry, QA/QC, Quality, R&D, RP-HPLC | Comments Off on Emerging Trends in Analytical R&D

Intellectual Property Management Group Focuses on API Innovation and Differentiation for Customers

With potential projected losses of $16-32 billion for drugs going off-patent in 2015, intellectual property (IP) is increasingly crucial to keeping a competitive edge in the pharmaceutical and biotechnology markets….

Posted in agreement, API synthesis, APIs, Chemistry, CMC, Contract Manufacturing, CRO/CMO, Freedom to Operate, IP, Patent, R&D, technology transfer | Comments Off on Intellectual Property Management Group Focuses on API Innovation and Differentiation for Customers

Green Chemistry and Benign by Design

7 ways to boost profits and reduce pharma synthesis waste At Neuland, we’re advocates of green chemistry. Not only is it better for the environment, but it’s also just logistically…

Posted in analytical science, API synthesis, APIs, atom economy, Benign-by-Design, Capabilities, Chemistry, CMC, Contract Manufacturing, EHS, energy conservation, energy effciency, green chemistry, ICH, Impurity profile, Quality, R&D, Route Design, Route Scouting, small molecule, synthesis, Synthesis Route, Uncategorized, zero liquid discharge | Comments Off on Green Chemistry and Benign by Design

No Straight Line: Confronting API Scale-Up Challenges

In many of the blog posts we’ve written over the last few years, we’ve referenced the growing complexity of active pharmaceutical ingredients (APIs). It isn’t just mindless chatter intended to…

Posted in CMC, Contract Manufacturing, CRO/CMO, R&D, Route Design, scale-up | Comments Off on No Straight Line: Confronting API Scale-Up Challenges

Peptide Process Chemistry – A New Era?

Since pioneers such as Bodanszky and Du Vigneaud first produced them synthetically in the 1950’s, peptides have always held tremendous – but unrealized – promise for human health. Despite their…

Posted in APIs, Capabilities, cardiovascular disease, Contract Manufacturing, drug delivery, genotoxic impurities, Neuland Labs, oncology, peptide, peptides, R&D, scale-up, transdermal | Comments Off on Peptide Process Chemistry – A New Era?

Contract Drug Manufacturing R&D: from Route Scouting to Kilo Labs

Let’s face it – ‘cost-effective capabilities’ is a big reason why CROs and CMOs continue to be a highly-popular drug commercialization route of choice. Where else can you find ready-to-go…

Posted in analytical science, Chemistry, CMC, Contract Manufacturing, CRO/CMO, R&D, Route Design | Comments Off on Contract Drug Manufacturing R&D: from Route Scouting to Kilo Labs

The Benefits of Synthesis Scouting

The Right Route Can Deliver Fewer Steps, More Consistent Batches, Cleaner Processes…and Cost Savings With drug development and manufacturing processes becoming more complex, alternate synthetic route design is often a…

Posted in Chemistry, CMC, Contract Manufacturing, CRO/CMO, EHS, green chemistry, method development, R&D, Route Design, Synthesis Route | Comments Off on The Benefits of Synthesis Scouting

You Can’t Keep a Good Drug Down

Reducing Mutagens, Carcinogens & Other Genotoxins to Improve Safety Profiles There are a number of process modifications API manufacturers can make to improve safety profiles, reduce production costs, improve capacity…

Posted in analytical science, APIs, Capabilities, Chemistry, CMC, Contract Manufacturing, critical reaction parameters, CRO/CMO, drugs, EHS, genotoxic impurities, green chemistry, method development, Neuland Labs, QA/QC, QbD, R&D, regulatory, Route Design, scale-up, Synthesis Route, zero liquid discharge | Comments Off on You Can’t Keep a Good Drug Down

APIs & Chemistry: The Importance of Understanding Critical Reaction Parameters

Active Pharmaceutical Ingredients (APIs, or – in layman’s terms – the ingredients that makes drugs work) have grown increasingly complex. Today’s equivalent of boiling tree bark into a tincture typically…

Posted in analytical science, Capabilities, Chemistry, critical reaction parameters, drugs, genotoxic impurities, method development, QA/QC, R&D, scale-up | Comments Off on APIs & Chemistry: The Importance of Understanding Critical Reaction Parameters

Neuland – Thirty Years of Global Pharma, Process Chemistry & APIs

Hitting a milestone such as 30 years old as a pharmaceutical manufacturing company is a pretty big deal. Pharma – as you can imagine – has changed. A lot. Thirty…

Posted in Capabilities, Chemistry, Contract Manufacturing, DMF, FDA, Neuland Labs, Project Management, R&D, regulatory, scale-up | Comments Off on Neuland – Thirty Years of Global Pharma, Process Chemistry & APIs